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Most cases of pyruvate dehydrogenase complex deficiency (at least 75%) are due to pathogenic or likely pathogenic variants in PDHA1 , with over 130 nonduplicate disease-causing variants reported (42
Besides podocytes, berberine can also upregulate the expression of CPT1 and PPAR in renal TECs, further improving mitochondrial FAO and reducing lipid accumulation in DKD mice (Rong et al., 2021)
1) Functions as an Important Antioxidant Glutathione is a powerful antioxidant found in the body
doi: 10.1038/s41388-021-01883-6
