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Design of oncology clinical trials: a review

Furthermore, targeting regulators within the crosstalk itself, such as knocking down deltex E3 ubiquitin ligase 2 to stabilize NCOA4 and promote ferritinophagy, can mitigate cisplatin resistance in NSCLC (121)

Roughly expressed, the qualifier agent-based means the dynamics of the computationally implemented system are driven by interactions among software entities called agents with encapsulated states (data, attributes, and/or methods), starting from initial user-specified conditions

[29, 30, 31] They can be delivered alone or in combination with immunomodulatory agents