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Mitochondrial ROS (mtROS) are detoxified by superoxide dismutase (SOD), which converts superoxide to hydrogen peroxide, followed by sequential clearance via catalase, glutathione peroxidase (GSH-Px), and the peroxiredoxin/thioredoxin (PRX/Trx) systems [85, 86]

However, on account of strict homeostatic regulation of plasma L-carnitine concentrations, higher doses of L-carnitine supplementation may not provide additional therapeutic benefits

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