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Tissue was placed in a sterile tissue culture plate with 5 ml of 2% collagenase in HBSS

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After 48 h of incubation, CCK-8 solution was added to each well and incubated for an additional 1 h

Table 1: Cytochrome P450 (CYP) Enzymes and Drugs/Substrate Interaction Major metabolizer = M Produces active metabolite =