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Mitochondrial dysfunction, identifiable through Krebs cycle intermediates on OAT, has been linked to persistent fatigue and neurocognitive symptoms in a systematic review by Rossignol and Frye (2012)

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repletion reverses hematologic symptoms within days and neurologic sequelae over weeks, reflecting differential tissue turnover

A clinical study investigating oxidative DNA damage in AD reported increased oxidative DNA damage in patients with AD and its correlation with alcohol withdrawal severity
