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This damages the electron transport chain in the mitochondria, which raises ROS production, aggravates OS, and encourages apoptosis
This study, conducted by Sharma et al., found that an increase in levels of 8-iso-PGF2-alpha resulted in lipid peroxidation and thus, oxidative stress
Moreover, the SAM:SAH ratio is markedly increased, while liver and kidney gnmt mRNA levels are decreased in the short-lived growth hormone transgenic mice (GH-Tg)
It implies that the body is returning to a state of relying on pure natural production, which is already decreasing because of old age or stress
