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Although SLNs and NLCs have proven to be potential candidates for the treatment of AD, as evidenced by their effectiveness in both hydrophilic and hydrophobic therapeutic agent transportation across the BBB (Dighe et al., 2023), NLCs have more recently emerged as the dominant platforms for an alternative intranasal administrationnose-to-brain delivery (Shehata et al., 2023b,a

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At this point, the answer is more restrained: Epitalon is biologically interesting, mechanistically plausible in some settings, and supported by a limited but intriguing body of preclinical and early translational literature