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In experimental models, suppression of spermatogenesis in the testes and degeneration of primordial follicles and granulosa cells in the ovaries are considered hallmark features of platinum-induced gonadotoxicity.8 Chemotherapeutic agents have been shown to deplete intracellular Glutathione (GSH), one of the major endogenous antioxidants, while simultaneously increasing Myeloperoxidase (MPO) activity, an indicator of inflammatory response, and elevating Malondialdehyde (MDA), a marker of lipid peroxidation.9 Co-administration of antioxidants during chemotherapy has therefore been proposed as a strategy to mitigate oxidative stress-induced tissue injury and improve therapeutic tolerance

doi:10.1002/pros.22619 Shaito A, Posadino AM, Younes N, etal

Expression vectors were co-transfected into Expi293F human suspension cells using ExpiFectamine (Thermo Fisher)

Article summary AI generated Iron deficiency in soil is a significant barrier to agricultural productivity and human health, particularly in regions with high pH soils where iron availability is limited