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10.1158/0008-5472.CAN-03-0799 99
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Cholesterol is oriented in lipid layers so that the four rings and the side chain tail are buried in the membrane in a parallel orientation to the fatty acid acyl chains on adjacent phospholipid molecules

Glycerol and phosphate part has polar properties (hydrophilic) and two fatty acid chains have nonpolar properties (hydrophobic)
