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There is evidence that the full inhibition of Complex I that prevents increased ROS generation impairs hypoxic adaptation in tumor cells by rewiring mitochondrial metabolism, and the antitumorigenic effect of ROS signaling is lost [39]
Genome Res 13 : 24982504
[DOI] [PubMed] [Google Scholar] Matsukawa J, Matsuzawa A, Takeda K, Ichijo H
51 This distinction underscores the differing mechanisms underlying malignant tumorigenesis in CAC compared to sporadic CRC (Figure 2)
