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Upon entry into the nucleus, MOTS-c interacts with a variety of stress response transcription factors, including nuclear factor red lineage 2-related factor 2 (NFE2L2/NRF2), as well as activating transcription factors 1 and 7 (ATF1/ATF7) [38]

doi: 10.1038/s41398-020-0830-x

Hirata F, Schiffmann E, Venkatasubramanian K, Salomon D, Axelrod J

Diagnosis is made by exclusion of alcohol abuse and other causes of liver disease (HBV-related hepatitis, HCV-related hepatitis, autoimmune liver diseases, polycystic ovary syndrome, drug-induced liver disease and congenital causes such as hereditary hemochromatosis, Wilsons disease, alpha-1 antitrypsin deficit)