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A double-blind, randomized, placebo-controlled trial employing 227 adults with chronic kidney diseases were taking 25 mg, 75 mg, or 150 mg of bardoxolone methyl every day for a period of 24 weeks or 52 weeks

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Targeting immunometabolism aims not only to restore effector immune cell function but also to disrupt tumor and cancer stem-like cells metabolic programs that contribute to immune evasion and therapeutic resistance