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Description
In induced pluripotent stem cell (iPSC)-derived midbrain organoid models deficient for DJ1 activity, we find that lysosomal proteolysis is impaired, causing AGEs to accumulate, -synuclein (-syn) phosphorylation to increase, and proteins to aggregate
Selhub et al, 1995
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Each subunit contains two functional domains: the N-terminal functional domain and the C-terminal functional domain
