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As PARP proteins require NAD + to act [67, 68], it is possible that the low NAD + levels in R cells may also reflect this mechanism

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was supported by the European Research Council (786602), the Novo Nordisk Foundation (NNF18OC0030274 and NNF20OC0064301), the Lundbeck Foundation (R359-2020-2287), the Danish National Research Foundation (DNRF164) and the Swedish Research Council (2021-00942)