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In the context of a scopolamine-induced AD rat model, observations within the hippocampus reveal that pre-treatment with VitB12 can not only effectively counter the decrease of neurexin 1 and neuroligin, and the elevation of COX-2 and activation of caspase-3 (markers employed to assess ADs severity and progression) but also alleviate the decline of postsynaptic density protein 95 (PSD-95), a scaffold protein that regulates synaptic maturation and plasticity

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GSTP1 is also involved in endogenous regulation of cellular signaling pathways (Fig