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Laboratory anomalies can reveal mild hyperglycemia, reduced serum cholesterol, or elevated liver transaminases, typically resolving after dose adjustment

The active factor turned out to be a small tripeptide that tightly bound copper

Because they can closely mimic other conditions, patients are frequently evaluated for gallbladder disease, gastritis or GERD, kidney stones, costochondritis, intercostal neuralgia, and cardiac conditions before a correct diagnosis is reached

There have been also attempts to develop CA IX antibody-drug conjugates, but in these approaches, both linker and drug are equally important as the antibody itself and all three components together determine the outcome of therapy and potential side effects, as it was in the case of the human 3ee9 antibody conjugated to monomethyl auristatin E through a self-cleavable linker (BAY 79-4620), which showed potent antitumor efficacy in several xenograft models [110], but failed in a clinical trial due to inacceptable toxicity