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Advantages: Localized delivery to target tissue (skin, scalp) Non-invasive Lower systemic exposure Well-tolerated with established safety record in cosmeceuticals Limitations: Limited dermal penetration (molecular weight ~340 Da near the cutoff for transdermal absorption) No systemic anti-aging or anti-inflammatory effects Efficacy dependent on formulation vehicle (liposomal carriers significantly improve penetration) GHK-Cu Injection (Subcutaneous) GHK-Cu injection is explored in research settings for systemic administration

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Moreover, 8-OHdG prevents DNMTs from binding to DNA, which causes the entire genome to be hypomethylated (Ziech et al., 2011

Concurrently, substantial preclinical research is exploring other delivery platforms and strategies