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This knowledge led to the hypothesis that increased levels of Gsto2 in iSPNs can disrupt AA homeostasis, leading to changes in TH protein levels and increased DA synthesis in striatal projecting mDA neurons that potentially express no or low TH in the adult brain

1 To use a simple analogy: if our cells have a shield, glutathione is the most important part of that shield

Oxidative products of lipid peroxidation, oxidative damage of hyaluronic acid, and oxidation of low-density carbonyl and lipoproteins increment have been observed in RA patients

To illustrate these links, Figure 2 summarizes how specific microbial exposures shape asthma endotypes