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Figure no10: Ex vivo release data (III.2.G) Stability Study :- When formulation is allow to expose at higher temperature(50?C,70?C,90?C) the amount of drug content tend to decrease rapidly and the color of the formulation get changed from red to orange This clearly indicate the degradation of methylcobalamine at elevated temperature

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Furthermore, DAG generated by PNPLA2 preferentially produces 1,3- DAG which cannot activate PKC (196), suggesting that the de novo generation of DAGs leads to insulin resistance

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