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Institute of Medicines Recommendations In their 1998 report, the IOM used the amount of B12 required to treat pernicious anemia as a basis for their recommendations for the general adult population (IOM, 1998)

Correspondingly, the parameters of KEGG enrichment were set as: min overlap = 3, p-value cutoff = 0.05, min enrichment = 1.5

Institutions like the Mayo Clinic and Cleveland Clinic emphasize that while Vitamin B12 for weight loss is popular, theres no strong clinical evidence that injections help shed pounds in people with normal B12 levels

It is important to note that B12 injections should only be used when there is a diagnosed deficiency or clear clinical indication