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doi: 10.1016/j.mrrev.2009.12.005 117 KasaiH

Chen and Asada, 1987

Activation of mTORC1 signaling has been found to inhibit the interaction between lysosomal NPC1 and mitochondrial translocator protein (TSPO), resulting in the untethering of mitochondria-lysosome contact sites and cholesterol accumulation, indicating that mTORC1 serves as a central component of lysosomal signaling, mediating cholesterol trafficking from lysosomes to mitochondria by modulating the interaction between NPC1 and TSPO (Lin et al., 2023)

It also causes your hair follicles to stand up (hello, goosebumps) and your muscles to tremor to generate heat