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By rationally designing a senolytic to FOXO4, we showed that we can eliminate senescent cancer cells and use combination treatments for senescence induction and apoptosis of cancer cells resulting in increased survival

As expected, treatment with 2-AAPA diminished cellular GSH levels and increased GSSG, thus significantly elevating the GSSG/GSH ratio, similar to the effects of etomoxir (Figure 4B)
Interestingly, the S284 and T291/T292 phospho-sites are localized within a unique motif termed ArfGAP1 lipid-packing sensor 2 (ALPS2), that consists of residues 264-295 [44, 45]

Several reports have shown that seizures lead to a decrease in GPX4 promoting oxidative stress [35, 45, 46]
