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Conducting your safety pharmacology study before the first administration in humans is the recommended and standard approach for maximizing safety and meeting regulatory requirements
doi: 10.1016/j.biopha.2005.07.003
The redox-sensitive proteome can be post-translationally modified through disulfide linkages between GSH and redox-sensitive cysteine residues within proteins, for example, S-glutathionylated (P-SSG)
