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Further analysis using the Hoechst DNA staining (Hoechst 33342 trihydrochloride dye) showed that curcumin induces cytotoxicity in p53+/+ and p53/ HCT-116 cells by causing changes in nuclear morphology, namely chromatin condensation, which indicated apoptosis induction

One explanation is that while antioxidants can initially protect cells, prolonged exposure might deplete intracellular antioxidant reserves and make cells more susceptible to damage

Mol Genet Metab 139: 107630, 2023

We included various study types to ensure a broad perspective on the topic, encompassing human clinical trials, animal models, cohort studies, case reports, meta-analyses, systematic reviews, guidelines, editorials, and review articles