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However, depending on the underlying mechanisms involved, it is possible that anti-tumor activity may require long term treatment and follow-up, e.g., over years rather than just the few weeks or months of most clinical trials

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This one principle explains why glycolic acid the smallest AHA is the most potent and fastest-acting but also the most likely to cause irritation, while PHAs which have the largest molecules of any exfoliating acid family are gentle enough for daily use on sensitive skin

Novo Nordisk filed a New Drug Application with the FDA in late December of the previous year for the weight management indication