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Additionally, following repeated drug exposures, habits might also result from a reduction in inputs from prefrontal cortex (PFC) into striatum that disrupt the control over action selection (269)

This spatial and transcriptional heterogeneity suggests that localized ferroptotic events may drive tissue damage by interfering with cartilage repair and intercellular communication

The repair signature is reminiscent of the copper signature very recently demonstrated in regulatory T cells, whose energetic and functional phenotype is highly dependent on free intracellular copper

So far, however, the Cu donator hypothesis through CuMT could not be verified