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Tsujii S, Ishisaka M, Shimazawa M, Hashizume T, Hara H

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[] Another 8-week trial involving 52 benign prostatic hyperplasia (BPH) patients demonstrated that combined supplementation of lycopene and FruHis resulted in a more significant reduction in insulin-like growth factor 1 (IGF-1), total prostate-specific antigen (TPSA), symptom score, body mass index (BMI), and waist circumference (WC) compared with either supplement alone, with a notable effect observed specifically for IGF-1

Receptor activator of NF-B ligand (RANKL) is a peptide type II transmembrane protein of the TNF superfamily that is associated with osteoclast differentiation and development, increases osteoclast bone resorption, and regulates its fate (220)