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Factors that regulate Wnt--catenin signaling in HF include androgen [51], BMP [52], soluble frizzled receptor protein-1 (sFRP1), and growth factors [53,54,55]

Similarly, Behmoaras et al (15) revealed that LOX and LOXL1 activities were at their highest during the first 15 days of development, which suggested that both LOXs may be required for elastin and collagen remodeling in the aorta of rats

The reasons for these discrepancies are unclear although a follow-up study from Erickson et al attributed the discrepant results to a lack of functional consequence in the ARE mutant used by Galloway and McLellan (Erickson et al., 2002)