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Various physiological and pathological conditions can lead to an accumulation of misfolded proteins in the ER lumena conserved adaptive reaction known as ER stress, and triggering the unfolded protein response (UPR) (Liu et al., 2017)
10.3389/fnut.2022.994971 92 QiuJ.ShiW.MiaoJ.HuH.GaoY
However, translational challenges persist, including the lack of pharmacokinetic standardization between oral and intravenous routes, tumor-type-specific response heterogeneity, and incomplete understanding of VCs immunomodulatory dynamics
Intracellular and extracellular labile iron pools
