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discovered that -ketoglutarate, as a cofactor for histone demethylases, inhibits TNF family member Tnfrsf12a/Fn14 expression-induced cachectic manifestations by reversing the glutamine deficiency-induced tri-methylation of lysine 4 on histone H3 (H3K4me3) enrichment at the Tnfrsf12a promoter, indicating the protective role of dimethyl -ketoglutarate 187 (Fig

J Urol 1999;162:2003-5

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