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Abbreviations PH: Pulmonary hypertension BMPR2: Bone morphogenetic protein receptor type II E2: Estradiol CYPs: Cytochrome P450s UGTs: UDP-glucuronosyltransferases 2-OHE2: 2-Hydroxyestradiol 4-OHE2: 4-Hydroxyestradiol 2-ME2: 2-Methoxyestradiol HSD17B: 17-Hydroxysteroid dehydrogenase 2-ME1: 2-Methoxyestrone 16-OHE: 16-Hydroxyestrone ER: Estrogen receptor PASMCs: Pulmonary arterial smooth muscle cells PAECs: Pulmonary arterial endothelial cells EndoMT: Endothelial mesenchymal transition ROS: Reactive oxygen species Nrf2: Nuclear factor E2-related factor 2 PPAR: Peroxisome proliferator-activated receptor HIF: Hypoxia-inducible factor SSc: Systemic sclerosis PAH: Pulmonary arterial hypertension ECs: Endothelial cells TGF-: Transforming growth factor- IL: Interleukin TNF: Tumor necrosis factor SMCs: Smooth muscle cells HASMCs: Human aortic smooth muscle cells GPR30: G protein-coupled receptor 30 GSTP: Glutathione S -transferase P COPD: Chronic pulmonary obstruction disease IGF: Insulin-like growth factor References Mocumbi A, Humbert M, Saxena A, Jing ZC, Sliwa K, Thienemann F, Archer SL, Stewart S

Descriptive studies have demonstrated the increased microbial diversity in the areas of the world where fiber intake is higher in the general diet

10.1021/pr7007835

This oxidative stress is not only involved in the toxicity of xenobiotics but also in the pathophysiology of various ailments like ischaemia reperfusion injury, vascular endothelium, deep injuries, organ dysfunction, shock, inflammation, sepsis, diabetic retinopathy, cancer, cognitive dysfunction, cataract, and heart disease