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Because MTHFR gene variations impair the bodys ability to convert B vitamins, methylated forms of B vitamins are considered the most bioavailable as they dont need any conversion by the body Consider high doses: you might need significant doses of methylcobalamin to treat a deficiency

Although the proposed adverse effects discussed above deserve scrutiny, a pre-clinical safety evaluation by Xu et al

Patients 65 years of age accounted for the majority (37%) of B 12 test volumes in 2019
