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In addition, in AD brain both 20S and 19S proteasomal complexes are targets of ox-PTMs, including the formation of HNE adducts, carbonylation, S -glutathionylation, glycoxidation, as well as ADP-ribosylation and phosphorylation (346, 355, 356)

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We discovered it makes cholinergic neurotransmission easier, either directly or by providing acetyl groups for acetylcholine synthesis [5]

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