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J Hepatol 2016;65:35462 [DOI] [PMC free article] [PubMed] [Google Scholar] 68.Wang H, Ni HM, Chao X, Ma X, Rodriguez YA, Chavan H, Wang S, Krishnamurthy P, Dobrowsky R, Xu DX, Jaeschke H, Ding WX.Double deletion of PINK1 and Parkin impairs hepatic mitophagy and exacerbates acetaminophen-induced liver injury in mice

These mutations include gain-of-function mutations of the MC2R, GNAS, the catalytic subunit of protein kinase A (PRKACA) and PRKACB genes and inactivating mutations of the regulatory subunit R1 of PKA ( PRKAR1A ), and of two cAMP-binding phosphodiesterases ( PDE11A and PDE8B ) genes, mimicking the action of ACTH to stimulate glucocorticoid production, providing a molecular basis for the pathogenesis of primary adrenal Cushing syndrome (22)