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Treatment of HCV and achievement of sustained virologic response (SVR) reduces the risk of developing manifestations of mixed cryoglobulinemia.[24] Cryoglobulinemic Vasculitis Clinical manifestations of cryoglobulinemia can vary with the most common presentation being vasculitis.[22] Chronic HCV is generally the most common underlying etiology, but lymphoproliferative disorders (with or without HCV) or autoimmune diseases such as Sjgren's or lupus can also be associated with cryoglobulinemic vasculitis