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Circ Res 122(4):560-7 2018 PMC5815899 Guo R, Hua Y, Ren J, Bornfeldt KE, Nair S
10.1016/j.bbagen.2015.10.005 Biochim
In other words, they found that increased intracellular doxorubicin in melanoma cells was mediated by the upregulation of the CT2 transporter
As the mitochondria become damaged, they leak their contents into the cellular cytoplasm, which the immune system recognizes as a danger signal, further amplifying the inflammatory response in a vicious, self-perpetuating cycle
