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There have also been several reported cases of strokes (cerebral ischemia) and other vascular thrombotic diseases because of the clotting issue associated with isotretinoin

102 NeitemeierS.JelinekA.LainoV.HoffmannL.EisenbachI.EyingR.et al (2017)

(3) Due to the limited study duration, the effectiveness and safety of the treatments were only evaluated after four treatments
[DOI] [PubMed] [Google Scholar] 30.Lu H., Tang S., Xue C., Liu Y., Wang J., Zhang W., Luo W., Chen J