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Curcumin prevents uPA transcription by suppressing NF-kB and STAT3, and its analogs (e.g., L48H37) prevent JAK/STAT-uPA by reducing cell invasion in osteosarcoma [204]

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Transcription factor Nrf2 has shown the ability, both in in vitro and in in vivo experiments, to activate a series of vitagenes including (Hsp) Hsp32, Hsp70, and thioredoxin, conferring protection against oxidative stress, and contributing to establish a cytoprotective state in inflammation and neurodegenerative disorders [135, 136]

The third important step is modifying EVs to improve their targeting capability