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It can also result in confusion and personality changes

That is the evidence gap, stated plainly: the mechanism is well-motivated and the preclinical signal is consistent, but no human study has confirmed that any of it translates to people, at any dose, by any route

Theranostics (2020) 10(14):626177
Another effect of aging is capillary loss, accompanied by a decline in SIRT1 activity and NAD + levels
