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This exceptional selectivity profile enables researchers to attribute observed effects specifically to NNMT inhibition, rather than off-target activities that plague less specific compounds

5-amino-1-methylquinolinium) combined with low-fat diet (LD) promoted dramatic whole-body adiposity and weight loss in diet-induced obese (DIO) mice, rapidly normalizing these measures to age-matched lean animals, while LD switch alone was unable to restore these measures to age-matched controls in the same time frame

What distinguishes 5-amino-1MQ in the research landscape is its exceptional selectivity profile and membrane permeability characteristics

Aging Cell