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It interacts with DNA to form adductssuch as DNADNA and DNAproteins crosslinkswhich activate several signal transduction pathways that trigger cell death 74,76

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This impaired the enzyme functions in the respiratory chain and ultimately leading to mitochondrial dysfunction, reduced mitochondrial biogenesis and a broad range of pathologic conditions such as aging, various metabolic diseases and neurodegenerative disorders [5, 12, 44, 46-52]

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