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Abnormal expression and dysfunction of KARs are associated with various neurological diseases and disorders, including schizophrenia, mood disorders, epilepsy, and Huntingtons disease 8,9,10,11,12,13,14,15,16,17

Although most experts agree on the importance of not discontinuing metformin because of its critical role in T2D management, it is essential to supplement vitamin B12 when a deficiency is identified, even without suggestive symptoms

The goal is to find the highest dose you can tolerate comfortably, not to reach the maximum dose as quickly as possible

[DOI] [PMC free article] [PubMed] [Google Scholar] 7.Sikiric P., Hahm K.B., Blagaic A.B., Tvrdeic A., Pavlov K.H., Petrovic A., Kokot A., Gojkovic S., Krezic I., Drmic D., et al