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Description
After binding with PERK, TMAO selectively activates PERK-mediated UPR, thereby promoting metabolic dysfunction ( Of note, TMAO in the pathogenesis of Alzheimers disease (AD) indicated that PERK is not the only mechanism by which TMAO induces UPR
It is taken as a supplement by professional sportspersons and those with fitness goals
10.1161/CIR.0b013e31820a55f5
J Am Coll Cardiol 1999;34:1618-24
