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Vahratian A, Lin J-MS, Bertolli J, Unger E

A hallmark of this differentiation process is the increased synthesis of phospholipids, particularly phosphatidylcholine (PC) (104), which supports the expansion of the intracellular membrane network, including the rough endoplasmic reticulum, where immunoglobulins are synthesized and assembled (105, 106) ( Figure 3 )

Many of these effects have been shown to persist beyond acute withdrawal, and this dopamine hypofunctional state has been suggested to underlie, in part, the negative affect and dysphoria associated with protracted abstinence, as well as the motivation to re-engage in alcohol-drinking behavior (Diana, 2011

Oral ALCAR supplementation seems to result in plasma levels that are higher than in healthy individuals