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In cell culture models of human macrophage foam cells, the inability to clear cholesterol from macrophages with compromised lysosome function continues even in the presence of compounds that stimulate efflux (161,163)

ABCC1 also leads to resistance to a wide range of anticancer drugs, and extensive evidence indicates that resistance of cancer cells to mitoxantrone, saquinavir, epipodophyllotoxins, and anthracyclines is mediated by ABCC1 [42,43,44,45]

10.3390/tropicalmed8090430 106 ScarpiniS.DondiA.TotaroC.BiagiC.MelchiondaF.ZamaD.et al (2022)

L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation
