glutathione protective against organix peroxides and peroxisome redox homeostasis Emerging mechanisms of lipid peroxidation

10.5483/BMBRep.2015.48.2.081 289 ShiW

This has driven the search for alternative therapeutic strategies, among which natural compounds, like curcumin, have drawn considerable interest due to their low toxicity and potent antitumor effects

The hydrazone is an acid labile group, and the ADC of the hydrazone linker is transported to acidic endosomes (pH 5.0-6.0) and lysosomes (pH about 4.8), where the free drug is released by hydrolysis

8 In practice, a 5-year-old with strep throat should receive penicillin or amoxicillin (first-line), or if allergic, perhaps azithromycin but not cefuroxime tablets as a first choice