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Pathophysiology beyond dopaminergic neuronal loss The alpha-synuclein model Alpha-synuclein is a presynaptic neuronal protein whose abnormal aggregation into Lewy bodies leads to disruption in cellular homeostasis and consequently neurodegeneration 7

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Studies of glyoxalase 1-linked Multidrug resistance reveal Glycolysis-derived reactive metabolite, Methylglyoxal, is a common contributor in cancer chemotherapy targeting the Spliceosome
Jiang GL, Yang XL, Zhou HJ, Long J, Liu B, Zhang LM, et al
