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It is an important concept in pharmacology, as it helps to determine the dosage and frequency of drug administration

The cost of dermal fillers is influenced by the type of filler, the number of areas being treated, the size of the area being treated, and the expertise of the professional performing the treatment
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A 2019 study in Dermatologic Surgery comparing localized versus systemic botulinum toxin for hyperhidrosis found that systemic administration produced more uniform results across larger treatment areas