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two trials [9] administered ALC orally, and the other two [10,11] administered sequentially through intramuscular and oral route

Introduction Primary melanocytic tumors of the central nervous system (CNS) are lesions derived from melanocytes and were first described in 1859 by Rudolf Virchow [ Unlike secondary melanomas that affect the CNS, which have a high incidence, primary melanocytic tumors of the CNS are rare, with an incidence of 0.7 cases per 10 million inhabitants per year [ In the latest classification of CNS neoplasms by the World Health Organization (WHO) in 2021, primary CNS melanocytic tumors were categorized into four types (Table 1): primary leptomeningeal melanoma, primary leptomeningeal melanocytoma, primary leptomeningeal melanomatosis, and primary leptomeningeal melanocytosis [ TABLE 1 Primary melanocytic tumors of the CNS - WHO, 2021

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