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Chechowska M, Gajewska J, Szczepanik E, Mazur J, Cychol A, Kuniar-Paka A, Ambroszkiewicz J (2025) Oxidative stress indicated by nuclear transcription factor Nrf2 and glutathione status in the blood of young children with autism spectrum disorder: pilot study

Interestingly, ursodeoxycholic acid (UDCA), the only medication approved by the FDA for the treatment of primary biliary cirrhosis [152], a chronic cholestatic disorder, and SAMe were able to raise nuclear Nrf2 level, block the increase in MafG and c-Maf expression, protect against the fall in expression of GSH synthetic enzymes and GSH levels in these models [90,136]